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The brand was originally created in 1983 by the late Franco Moschino (1950–1994). Moschino and his fashion label became famous for his innovative, colorful – sometimes eccentric – designs, for his criticisms of the fashion industry and for his social awareness campaigns in the early 1990s. After Moschino's untimely death, Rossella Jardini, his former assistant, became creative director. The brand has been part of the Aeffe fashion group since 1999.

The brand consists of multiple lines: Moschino (main line for women and men), Moschino Cheap and Chic (women's secondary line, created in 1988), Love Moschino (diffusion line for men and women, identified in order of exclusivity . also, fashion accessories, jewelry, perfumes and cosmetics. in Milan, Moschino Hotel opened its concept in 2009, which is called "Maison Moschino".

Since 2013 the house has the creative direction of the flamboyant and controversial American designer Jeremy Scott.